Brand  (β version)

PDB ID: 6AWP

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
CLR Cholesterol PoSSuM
FVX Fluvoxamine PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 6AWP   PDBj   RCSB PDB   PDBe
Header : TRANSPORT PROTEIN
Title : X-ray structure of the ts3 human serotonin transporter complexed with fluvoxamine at the central site
Release Data : 2017-10-25
Compound :
mol_id molecule chains synonym
1 Sodium-dependent serotonin transporter A SERT,5HT transporter,5HTT,Solute carrier family 6 member 4
fragment: residues 76-618
mutation: Y110A, I291A, T439S, C554A, C580A
mol_id molecule chains
2 8B6 antibody FAB heavy chain B
mol_id molecule chains
3 8B6 antibody FAB light chain C
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: SLC6A4, HTT, SERT
expression_system_common: Human
expression_system_cell_line: HEK293S GnTI-
mol_id organism_scientific organism_common expression_system
2 Mus musculus  (taxid:10090) Mouse Spodoptera frugiperda  (taxid:7108)
gene: HC
expression_system_common: Fall armyworm
mol_id organism_scientific organism_common expression_system
3 Mus musculus  (taxid:10090) Mouse Spodoptera frugiperda  (taxid:7108)
gene: LC
expression_system_common: Fall armyworm
Authors : Coleman, J.A., Gouaux, E.
Keywords : Neurotransmitter transporter, antidepressant, TRANSPORT PROTEIN
Exp. method : X-RAY DIFFRACTION ( 3.800 Å )
Citation :

Structural basis for recognition of diverse antidepressants by the human serotonin transporter.

Coleman, J.A.,Gouaux, E.
(2018)  Nat. Struct. Mol. Biol.  25 : 170 - 175

PubMed: 29379174
DOI: 10.1038/s41594-018-0026-8

Reaction

Chain : A
UniProt : P31645 (SC6A4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H(+)(in) + K(+)(in) + Na(+)(out) + serotonin(out) = H(+)(out) + K(+)(out) + Na(+)(in) + serotonin(in) - PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672
left-to-right PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672
Chain : B
UniProt : A0A0F7R1P3 (A0A0F7R1P3_MOUSE)
Reaction : -
Chain : C
UniProt : A0A0F7R5U8 (A0A0F7R5U8_MOUSE)
Reaction : -