Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CL Chloride ion
CLR Cholesterol
FVX Fluvoxamine
NA Sodium ion
NAG N-acetyl-D-glucosamine
Code : 6AWP
Header : TRANSPORT PROTEIN
Title : X-ray structure of the ts3 human serotonin transporter complexed with fluvoxamine at the central site
Release Data : 2017-10-25
Compound :
mol_id molecule chains synonym
1 Sodium-dependent serotonin transporter A SERT,5HT transporter,5HTT,Solute carrier family 6 member 4
fragment: residues 76-618
mutation: Y110A, I291A, T439S, C554A, C580A
mol_id molecule chains
2 8B6 antibody FAB heavy chain B
mol_id molecule chains
3 8B6 antibody FAB light chain C
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: SLC6A4, HTT, SERT
expression_system_common: Human
expression_system_cell_line: HEK293S GnTI-
mol_id organism_scientific organism_common expression_system
2 Mus musculus  (taxid:10090) Mouse Spodoptera frugiperda  (taxid:7108)
gene: HC
expression_system_common: Fall armyworm
mol_id organism_scientific organism_common expression_system
3 Mus musculus  (taxid:10090) Mouse Spodoptera frugiperda  (taxid:7108)
gene: LC
expression_system_common: Fall armyworm
Authors : Coleman, J.A., Gouaux, E.
Keywords : Neurotransmitter transporter, antidepressant, TRANSPORT PROTEIN
Exp. method : X-RAY DIFFRACTION ( 3.800 Å )
Citation :

Structural basis for recognition of diverse antidepressants by the human serotonin transporter.

Coleman, J.A.,Gouaux, E.
(2018)  Nat. Struct. Mol. Biol.  25 : 170 - 175

PubMed: 29379174
DOI: 10.1038/s41594-018-0026-8

Chain : A
UniProt : P31645 (SC6A4_HUMAN)
Reaction : -
Chain : B
UniProt : A0A0F7R1P3 (No found in current UniProtKB/SwissProt)
Reaction : -
Chain : C
UniProt : A0A0F7R5U8 (No found in current UniProtKB/SwissProt)
Reaction : -