Brand  (β version)

PDB ID: 6AWE

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
C0J 2-fluoro-6-{[2-(pyridin-2-yl)ethyl]amino}benzonitrile PoSSuM
DMS Dimethyl sulfoxide PoSSuM
Non-standard Residues
Code Name Show
CME S,S-(2-hydroxyethyl)thiocysteine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6AWE   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 2-fluoro-6-(2-pyridin-2-ylethylamino)benzonitrile
Release Data : 2018-09-12
Compound :
mol_id molecule chains synonym
1 Purine nucleoside phosphorylase A Inosine-guanosine phosphorylase
ec: 2.4.2.1
Source :
mol_id organism_scientific organism_common expression_system
1 Schistosoma mansoni  (taxid:6183) Blood fluke Escherichia coli  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_plasmid: pOPINS3C
Authors : Faheem, M., Neto, J.B., Collins, P., Pearce, N.M., Valadares, N.F., Bird, L., Pereira, H.M., Delft, F.V., Barbosa, J.A.R.G.
Keywords : Purine Nucleoside Phosphorylase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.650 Å )
Citation :

Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 2-fluoro-6-(2-pyridin-2-ylethylamino)benzonitrile

Faheem, M.,Neto, J.B.,Collins, P.  et al.
To Be Published 

Reaction

Chain : A
UniProt : A0A0U3AGT1 (A0A0U3AGT1_SCHMA)
Reaction: EC: Evidence:
Physiological Direction:
2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + guanine 2.4.2.1 ARBA:ARBA00023929
-
2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + hypoxanthine 2.4.2.1 ARBA:ARBA00023950
-
guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine 2.4.2.1 ARBA:ARBA00023970
-
inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine 2.4.2.1 ARBA:ARBA00023918
-