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Ligands
Code Name Style Show Link
CL Chloride ion
CQM Citramalyl-CoA
GOL Glycerol
MG Magnesium ion
PO4 Phosphate ion
PYR Pyruvic acid
Non-standard Residues
Code Name Show
CSO S-hydroxycysteine
Glycosylation
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Code : 6AQ4   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : CRYSTAL STRUCTURE OF PROTEIN CiTE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MAGNESIUM, PYRUVATE AND CITRAMALYL-COA
Release Data : 2018-08-01
Compound :
mol_id molecule chains
1 Citrate lyase subunit beta-like protein A,B,C
ec: 4.1.-.-
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis H37Rv  (taxid:83332) Escherichia coli K-12  (taxid:83333)
gene: citE, Rv2498c
Authors : Fedorov, A.A., Fedorov, E.V., Wang, H., Bonanno, J.B., Carvalho, L., Almo, S.C.
Keywords : Mycobacterium tuberculosis, CitE, Citramalyl-CoA, TIM-barrel fold, trimer, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.825 Å )
Citation :

An essential bifunctional enzyme inMycobacterium tuberculosisfor itaconate dissimilation and leucine catabolism.

Wang, H.,Fedorov, A.A.,Fedorov, E.V.  et al.
(2019)  Proc.Natl.Acad.Sci.USA  116 : 15907 - 15913

PubMed: 31320588
DOI: 10.1073/pnas.1906606116

Discovery of a novel stereospecific beta-hydroxyacyl-CoA lyase/thioesterase shared by three metabolic pathways in Mycobacterium tuberculosis

Wang, H.,Fedorov, A.A.,Fedorov, E.V.  et al.
(2018)  Biorxiv 

DOI: 10.1101/322404

Chain : A, B, C
UniProt : P9WPE1 (CITEL_MYCTU)
Reaction : -