Het-PDB Navi2 (PDB: 6AOG)

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Ligands
Code	Name	Link
CB3	10-propargyl-5,8-dideazafolic acid	PoSSuM
CP6	5-(4-chloro-phenyl)-6-ethyl-pyrimidine-2,4-diamine	PoSSuM
NDP	Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate	PoSSuM
UMP	2'-deoxyuridine 5'-monophosphate	PoSSuM

Non-standard Residues
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Download interaction data: 6AOG

Code :

6AOG PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine (pyrimethamine)

Release Data :

2018-08-22

Compound :

mol_id	molecule	chains	synonym
1	Bifunctional dihydrofolate reductase-thymidylate synthase	A,B	DHFR-TS
	ec: 1.5.1.3, 2.1.1.45

Source :

mol_id	organism_scientific	expression_system
1	Toxoplasma gondii (taxid:5811)	Escherichia coli (taxid:562)

Authors :

Thomas, S.B., Li, Y., Chen, Z., Lu, H.

Keywords :

Toxoplasma gondii, Pyrimethamine, DHFR, OXIDOREDUCTASE

Exp. method :

X-RAY DIFFRACTION ( 3.2 Å )

Citation :

Identification of selective, brain penetrant Toxoplasma gondii dihydrofolate reductase inhibitors for the treatment of toxoplasmosis

Thomas, S.B.,Hopper, A.
To Be Published

PDB ID: 6AOG