PDB ID: 6AN4
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Code | Name | Style | Show | Link | |
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CL | Chloride ion | PoSSuM | |||
J1F | ((2-(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carboxamido)-N-(2-((((2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)amino)-2-oxoethyl)acetamido)methyl)phosphonic acid | PoSSuM |
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Download interaction data: 6AN4
Structure summary
Code : | 6AN4 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/INHIBITOR | ||||||||||||
Title : | Crystal structure of Escherichia coli HPPK in complex with bisubstrate analogue inhibitor HP-39 (J1F) | ||||||||||||
Release Data : | 2018-08-15 | ||||||||||||
Compound : |
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Source : |
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Authors : | Shaw, G.X., Shi, G., Ji, X. | ||||||||||||
Keywords : | alpha beta, TRANSFERASE-INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.4700 Å ) | ||||||||||||
Citation : |
Bisubstrate analog inhibitors of HPPK: Transition state mimetics
Shaw, X.G.,Shi, G.,Ji, X.
Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: Synthesis and biochemical and crystallographic studies
Shi, G.,Blaszczyk, J.,Ji, X.
et al.
Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New designnnnn with improved properties
Shi, G.,Shaw, G.,Liang, Y.-H.
et al.
Bisubstrate analog inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New lead exhibits a distinct binding mode
Shi, G.,Shaw, G.,Li, Y.
et al.
Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis
Shi, G.,Shaw, G.,Li, Y.
et al.
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Reaction
Chain : | A | ||||||||
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UniProt : | P26281 (HPPK_ECOLI) | ||||||||
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