Brand  (β version)

PDB ID: 6AIM

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Ligands
Code Name Style Show Link
9Z3 N-[(2r)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl-L-cysteine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6AIM   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Cab2 mutant H337A complex with phosphopantothenate-cysteine
Release Data : 2019-03-20
Compound :
mol_id molecule chains synonym
1 Phosphopantothenate--cysteine ligase CAB2 A,B Coenzyme A biosynthesis protein 2,Phosphopantothenoylcysteine synthetase,PPC synthetase
ec: 6.3.2.5
mutation: H337A
Source :
mol_id organism_scientific organism_common expression_system
1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast Escherichia coli  (taxid:562)
strain: ATCC 204508 / S288c
atcc: 204508
gene: CAB2, YIL083C
Authors : Zheng, P., Zhu, Z.
Keywords : complex, Phosphopantothenate--cysteine, LIGASE
Exp. method : X-RAY DIFFRACTION ( 2.0400 Å )
Citation :

Crystallographic Analysis of the Catalytic Mechanism of Phosphopantothenoylcysteine Synthetase from Saccharomyces cerevisiae.

Zheng, P.,Zhang, M.,Khan, M.H.  et al.
(2019)  J. Mol. Biol.  431 : 764 - 776

PubMed: 30653991
DOI: 10.1016/j.jmb.2019.01.012

Reaction

Chain : A, B
UniProt : P40506 (PPCS_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine 6.3.2.5 -
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