Brand  (β version)

PDB ID: 6AGX

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Ligands
Code Name Style Show Link
9WX Ethyl [4-({3-[2-(3,5-dimethoxyphenyl)ethyl]-5h-pyrrolo[2,3-B]pyrazin-5-yl}sulfonyl)-1h-imidazol-1-yl]acetate PoSSuM
Non-standard Residues
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PTR O-phosphotyrosine
Glycosylation
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Structure summary

Code : 6AGX   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/INHIBITOR
Title : The cocrystal structure of FGFR2 bound with compound 14 harboring 5H-pyrrolo[2,3-B]pyrazine scaffold
Release Data : 2019-08-21
Compound :
mol_id molecule chains synonym
1 Fibroblast growth factor receptor 2 A,B,C,D FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor
ec: 2.7.10.1
fragment: UNP residues 467-764
mutation: A628T
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli 'BL21-Gold(DE3)pLysS AG'  (taxid:866768)
gene: FGFR2
Authors : Xiong, B.
Keywords : Tyrosine-protein kinase, TRANSFERASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.9500 Å )
Citation :

The cocrystal structure of FGFR2 bound with compound 14 harboring 5H-pyrrolo[2,3-b]pyrazine scaffold

Xiong, B.
To be published 

Reaction

Chain : A, B, C, D
UniProt : P21802 (FGFR2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:16844695, PubMed:18056630, PubMed:19410646, PubMed:21454610
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