Brand  (β version)

PDB ID: 6AGT

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Ligands
Code Name Style Show Link
9X0 N-(cyclohexylmethyl)-4-oxo-4h-1-benzopyran-2-carboxamide PoSSuM
CO Cobalt (II) ion PoSSuM
FMT Formic acid PoSSuM
MLA Malonic acid PoSSuM
LYS Lysine PoSSuM
Non-standard Residues
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Structure summary

Code : 6AGT   PDBj   RCSB PDB   PDBe
Header : LIGASE/INHIBITOR
Title : Crystal structure of PfKRS complexed with chromone inhibitor
Release Data : 2019-03-13
Compound :
mol_id molecule chains synonym
1 Lysine--tRNA ligase A,B,C,D Lysyl-tRNA synthetase
ec: 6.1.1.6
Source :
mol_id organism_scientific expression_system
1 Plasmodium falciparum  (taxid:5843) Escherichia coli  (taxid:562)
gene: PFNF54_04763
Authors : Yogavel, M., Sharma, A., Sharma, A., Baragana, B., Walpole, C.
Keywords : KRS, CHROMONE INHIBITOR, AMINOACYLATION, ATP BINDING PROTEIN, LIGASE-INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.9530 Å )
Citation :

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Baragana, B.,Forte, B.,Choi, R.  et al.
(2019)  Proc. Natl. Acad. Sci. U.S.A.  116 : 7015 - 7020

PubMed: 30894487
DOI: 10.1073/pnas.1814685116

Reaction

Chain : A, B, C, D
UniProt : W7JP72 (W7JP72_PLAFO)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl- tRNA(Lys) 6.1.1.6 ARBA:ARBA00000204, RuleBase:RU003748
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