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Ligands
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9XC 3,5-bis(azanyl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide
Non-standard Residues
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Glycosylation
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Code : 6AG3   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of uPA in complex with 3,5-bis(azanyl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide
Release Data : 2019-09-18
Compound :
mol_id molecule chains synonym
1 Urokinase-type plasminogen activator U uPA
ec: 3.4.21.73
mutation: C122A, N145Q
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Komagataella pastoris  (taxid:4922)
gene: PLAU
Authors : Buckley, B., Jiang, L.G., Majed, H., Huang, M.D., Kelso, M., Ranson, M.
Keywords : Urokinase, Amiloride, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.4800 Å )
Citation :

uPA-HMA

Buckley, B.,Jiang, L.G.,Huang, M.D.  et al.
To Be Published 

Chain : U
UniProt : P00749 (UROK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin. 3.4.21.73 -
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