Het-PDB Navi2 (PDB: 6AFK)

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Ligands
Code	Name		Style	Show	Link
9WO	N-{(3s)-1-[3-(pyridin-4-yl)-1h-pyrazol-5-yl]piperidin-3-yl}-1h-indole-2-carboxamide				PoSSuM
SAM	S-adenosylmethionine				PoSSuM

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Download interaction data: 6AFK

Code :

6AFK PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of TrmD from Pseudomonas aeruginosa in complex with active-site inhibitor

Release Data :

2019-08-14

Compound :

mol_id	molecule	chains	synonym
1	tRNA (guanine-N(1)-)-methyltransferase	A,B	M1G-methyltransferase,tRNA [GM37] methyltransferase
	ec: 2.1.1.228 fragment: UNP residues 5-250

Source :

mol_id	organism_scientific	expression_system
1	Pseudomonas aeruginosa UCBPP-PA14 (taxid:208963)	Escherichia coli (taxid:562)
	strain: UCBPP-PA14 gene: trmD

Authors :

Zhong, W., Koay, A., Wong, Y.W., Sahili, A.E., Nah, Q., Kang, C., Poulsen, A., Chionh, Y.K., McBee, M., Matter, A., Hill, J., Lescar, J., Dedon, P.C.

Keywords :

tRNA methyltransferase, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.75 Å )

Citation :

Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors.

Zhong, W.,Koay, A.,Ngo, A. et al.
(2019) Acs Infect Dis. 5 : 326 - 335

Chain :

A, B

UniProt :

Q02RL6 (TRMD_PSEAB)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)- methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine	2.1.1.228	HAMAP-Rule:MF_00605
	-	HAMAP-Rule:MF_00605

PDB ID: 6AFK