Het-PDB Navi2 (PDB: 6ADI)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
9UO	6-(6-chloropyridin-2-yl)-n2,n4-bis[(2r)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine				PoSSuM
NDP	Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 6ADI

Code :

6ADI PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal Structures of IDH2 R140Q in complex with AG-881

Release Data :

2018-09-05

Compound :

mol_id	molecule	chains	synonym
1	Isocitrate dehydrogenase [NADP], mitochondrial	A,B	IDH,ICD-M,IDP,NADP(+)-specific ICDH,Oxalosuccinate decarboxylase
	ec: 1.1.1.42 fragment: UNP residues 41-452 mutation: R140Q

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: IDH2

Authors :

Ma, R., Yun, C.H.

Keywords :

Oxidoreductase

Exp. method :

X-RAY DIFFRACTION ( 1.969 Å )

Citation :

Crystal structures of pan-IDH inhibitor AG-881 in complex with mutant human IDH1 and IDH2

Ma, R.,Yun, C.H.
(2018) Biochem. Biophys. Res. Commun. 503 : 2912 - 2917

Chain :

A, B

UniProt :

P48735 (IDHP_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH	1.1.1.42	PubMed:22416140, PubMed:19228619
D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH	-	PubMed:22416140, PubMed:19228619

PDB ID: 6ADI