Het-PDB Navi2 (PDB: 6ADG)

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Ligands
Code	Name	Link
NDP	Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate	PoSSuM
MG	Magnesium ion	PoSSuM
9UO	6-(6-chloropyridin-2-yl)-n2,n4-bis[(2r)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine	PoSSuM

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Download interaction data: 6ADG

Code :

6ADG PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal Structures of IDH1 R132H in complex with AG-881

Release Data :

2018-09-05

Compound :

mol_id	molecule	chains	synonym
1	Isocitrate dehydrogenase [NADP] cytoplasmic	A,B,C	Cytosolic NADP-isocitrate dehydrogenase
	ec: 1.1.1.42 mutation: R132H

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: IDH1

Authors :

Ma, R., Yun, C.H.

Keywords :

IDH1, OXIDOREDUCTASE

Exp. method :

X-RAY DIFFRACTION ( 3.000 Å )

Citation :

Crystal structures of pan-IDH inhibitor AG-881 in complex with mutant human IDH1 and IDH2

Ma, R.,Yun, C.H.
(2018) Biochem. Biophys. Res. Commun. 503 : 2912 - 2917

PDB ID: 6ADG