Het-PDB Navi2 (PDB: 6AAM)

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Ligands
Code	Name		Style	Show	Link
9T6	4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-B]pyridine-5-carboxamide				PoSSuM

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Download interaction data: 6AAM

Code :

6AAM PDBj RCSB PDB PDBe

Header :

TRANSFERASE/INHIBITOR

Title :

Crystal structure of TYK2 in complex with peficitinib

Release Data :

2018-08-15

Compound :

mol_id	molecule	chains
1	Non-receptor tyrosine-protein kinase TYK2	A
	ec: 2.7.10.2 mutation: D1023N, I1114L,K972A,E971A,Q969A,C936A,C1142A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: TYK2

Authors :

Nomura, N., Tomimoto, Y.

Keywords :

protein kinase, TRANSFERASE-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.98 Å )

Citation :

Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor

Hamaguchi, H.,Amano, Y.,Moritomo, A. et al.
(2018) Bioorg. Med. Chem. 26 : 4971 - 4983

Chain :

UniProt :

P29597 (TYK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PubMed:10542297, PubMed:7526154
	-	PubMed:10542297, PubMed:7526154

PDB ID: 6AAM