Het-PDB Navi2 (PDB: 6AAJ)

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Ligands
Code	Name		Style	Show	Link
9T6	4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-B]pyridine-5-carboxamide				PoSSuM

Non-standard Residues
Code	Name	Show
PTR	O-phosphotyrosine

Glycosylation
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Download interaction data: 6AAJ

Code :

6AAJ PDBj RCSB PDB PDBe

Header :

TRANSFERASE/INHIBITOR

Title :

Crystal structure of JAK2 in complex with peficitinib

Release Data :

2018-08-15

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase JAK2	A,B	Janus kinase 2,JAK-2
	ec: 2.7.10.2 fragment: UNP residues 834-1132 mutation: K943A, K945A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: JAK2

Authors :

Amano, Y., Tateishi, Y.

Keywords :

protein kinase, TRANSFERASE-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.37 Å )

Citation :

Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor

Hamaguchi, H.,Amano, Y.,Moritomo, A. et al.
(2018) Bioorg. Med. Chem. 26 : 4971 - 4983

Chain :

A, B

UniProt :

O60674 (JAK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:15690087, PubMed:16174768, PubMed:7615558, PubMed:9618263
	-
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000305	Mn(2+) was used in the in vitro kinase assay but Mg(2+) is likely to be the in vivo cofactor.

PDB ID: 6AAJ