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Ligands
Code Name Style Show Link
9QO 5-(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-6-ethylpyrimidine-2,4-diamine
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate
SO4 Sulfate ion
Non-standard Residues
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Glycosylation
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Code : 6A7C   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Human dihydrofolate reductase complexed with NADPH and BT1
Release Data : 2019-04-10
Compound :
mol_id molecule chains
1 Dihydrofolate reductase A
ec: 1.5.1.3
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: DHFR
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET17b
Authors : Vanichtanankul, J., Tarnchompoo, B., Chitnumsub, P., Kamchonwongpaisan, S., Yuthavong, Y.
Keywords : DHFR, antifolate, inhibitor, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.0600 Å )
Citation :

Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance.

Tarnchompoo, B.,Chitnumsub, P.,Jaruwat, A.  et al.
(2018)  ACS Med Chem Lett  9 : 1235 - 1240

PubMed: 30613332
DOI: 10.1021/acsmedchemlett.8b00389

Chain : A
UniProt : P00374 (DYR_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH 1.5.1.3 PROSITE- ProRule:PRU00660, PubMed:12096917, PubMed:15039552, PubMed:17569517, PubMed:19196009, PubMed:19478082, PubMed:21876184, PubMed:9719595
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