Brand  (β version)

PDB ID: 6A6K

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Ligands
Code Name Style Show Link
9S6 3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol PoSSuM
Non-standard Residues
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Structure summary

Code : 6A6K   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000
Release Data : 2019-04-10
Compound :
mol_id molecule chains synonym
1 Estrogen-related receptor gamma A,B,C ERR gamma-2,Estrogen receptor-related protein 3
fragment: UNP residues 222-458
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ESRRG, ERR3, ERRG2
Authors : Yoon, H., Kim, J., Chin, J., Cho, S.J., Song, J.
Keywords : Sodium iodide symporter (NIS), Anaplastic thyroid cancer, Estrogen-related receptor gamma, Radioiodine therapy, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.900 Å )
Citation :

Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-gamma Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.

Kim, J.,Song, J.,Ji, H.D.  et al.
(2019)  J. Med. Chem.  62 : 1837 - 1858

PubMed: 30657313
DOI: 10.1021/acs.jmedchem.8b01296

Reaction

Chain : A, B, C
UniProt : P62508 (ERR3_HUMAN)
Reaction : -