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Ligands
Code Name Style Show Link
064 3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid
9CR (9cis)-retinoic acid
Non-standard Residues
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Glycosylation
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Modification
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Code : 6A60   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal structure of human FXR/RXR-LBD heterodimer bound to GW4064 and 9cRA and SRC1
Release Data : 2018-10-10
Compound :
mol_id molecule chains synonym
1 Bile acid receptor A Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14,RXR-interacting protein 14
fragment: ligand binding domain
mutation: C432E, C466E
mol_id molecule chains
2 Nuclear receptor coactivator 1 B,F
fragment: ligand binding domain
mol_id molecule chains synonym
3 Retinoic acid receptor RXR-alpha D Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: NR1H4, BAR, FXR, HRR1, RIP14
expression_system_strain: Rosetta2(DE3)
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
synthetic: yes
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: RXRA, NR2B1
Authors : Wang, N., Liu, J.
Keywords : Nuclear receptor heterodimer, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 3.0500 Å )
Citation :

Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding

Wang, N.,Zou, Q.,Xu, J.  et al.
(2018)  J. Biol. Chem.  293 : 18180 - 18191

PubMed: 30275017
DOI: 10.1074/jbc.RA118.004652

Chain : A
UniProt : Q96RI1 (NR1H4_HUMAN)
Reaction : -
Chain : B, F
UniProt : B5MCN7 (B5MCN7_HUMAN)
Reaction : -
Chain : D
UniProt : P19793 (RXRA_HUMAN)
Reaction : -