PDB ID: 6A60
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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064 | 3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid | PoSSuM | |||
9CR | (9cis)-retinoic acid | PoSSuM |
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Download interaction data: 6A60
Structure summary
Code : | 6A60 PDBj RCSB PDB PDBe | ||||||||||||||||||||||||||||||||||||
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Header : | TRANSCRIPTION | ||||||||||||||||||||||||||||||||||||
Title : | Crystal structure of human FXR/RXR-LBD heterodimer bound to GW4064 and 9cRA and SRC1 | ||||||||||||||||||||||||||||||||||||
Release Data : | 2018-10-10 | ||||||||||||||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Wang, N., Liu, J. | ||||||||||||||||||||||||||||||||||||
Keywords : | Nuclear receptor heterodimer, TRANSCRIPTION | ||||||||||||||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 3.0500 Å ) | ||||||||||||||||||||||||||||||||||||
Citation : |
Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
Wang, N.,Zou, Q.,Xu, J.
et al.
PubMed: 30275017 |
Reaction
Chain : | A |
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UniProt : | Q96RI1 (NR1H4_HUMAN) |
Reaction : | - |
Chain : | B, F |
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UniProt : | B5MCN7 (B5MCN7_HUMAN) |
Reaction : | - |
Chain : | D |
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UniProt : | P19793 (RXRA_HUMAN) |
Reaction : | - |