Brand  (β version)

PDB ID: 6A5Z

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Ligands
Code Name Style Show Link
9R3 2-[(1r,5s)-9-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-3-azabicyclo[3.3.1]nonan-3-yl]-1,3-benzothiazole-6-carboxylic acid PoSSuM
9CR (9cis)-retinoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6A5Z   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal structure of human FXR/RXR-LBD heterodimer bound to HNC180 and 9cRA and SRC1
Release Data : 2018-10-10
Compound :
mol_id molecule chains synonym
1 Bile acid receptor A,H Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14,RXR-interacting protein 14
fragment: ligand binding domain
mutation: C432E, C466E
mol_id molecule chains synonym
2 Retinoic acid receptor RXR-alpha D,L Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha
fragment: ligand binding domain
mol_id molecule chains
3 Nuclear receptor coactivator 1 E,F,G,I
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: NR1H4, BAR, FXR, HRR1, RIP14
expression_system_strain: Rosetta2(DE3)
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: RXRA, NR2B1
expression_system_strain: Rosetta2(DE3)
mol_id organism_scientific organism_common
3 Homo sapiens  (taxid:9606) Human
synthetic: yes
Authors : Wang, N., Liu, J.
Keywords : nuclear receptor heterodimer, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.9500 Å )
Citation :

Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding

Wang, N.,Zou, Q.,Xu, J.  et al.
(2018)  J. Biol. Chem.  293 : 18180 - 18191

PubMed: 30275017
DOI: 10.1074/jbc.RA118.004652

Reaction

Chain : A, H
UniProt : Q96RI1 (NR1H4_HUMAN)
Reaction : -
Chain : D, L
UniProt : P19793 (RXRA_HUMAN)
Reaction : -
Chain : E, F, G, I
UniProt : B5MCN7 (B5MCN7_HUMAN)
Reaction : -