Brand  (β version)

PDB ID: 6A1C

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Ligands
Code Name Style Show Link
9NX 5-bromanyl-2-methoxy-4-[(E)-(3-methylsulfanyl-5-phenyl-1,2,4-triazol-4-yl)iminomethyl]phenol PoSSuM
EDO 1,2-ethanediol PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6A1C   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of the CK2a1-go289 complex
Release Data : 2019-03-06
Compound :
mol_id molecule chains synonym
1 Casein kinase II subunit alpha A CK II alpha
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CSNK2A1, CK2A1
Authors : Kinoshita, T., Tsuyuguchi, M.
Keywords : CK2a1, Inhibitor, Complex, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.68 Å )
Citation :

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.

Oshima, T.,Niwa, Y.,Kuwata, K.  et al.
(2019)  Sci Adv  5 : eaau9060 - eaau9060

PubMed: 30746467
DOI: 10.1126/sciadv.aau9060

Reaction

Chain : A
UniProt : P68400 (CSK21_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20545769, PubMed:20625391, PubMed:21482717, PubMed:22017874, PubMed:22184066, PubMed:23123191, PubMed:28512243, PubMed:30699359, PubMed:30898438, PubMed:31439799
left-to-right PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20545769, PubMed:21482717, PubMed:23123191, PubMed:28512243, PubMed:30699359, PubMed:30898438, PubMed:31439799, PubMed:35597237
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20625391, PubMed:22325354, PubMed:31439799
left-to-right PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:31439799