Brand  (β version)

PDB ID: 5ZYI

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Ligands
Code Name Style Show Link
9ML 2-[4-[4-pentyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5ZYI   PDBj   RCSB PDB   PDBe
Header : LIPID TRANSPORT
Title : Crystal structure of CERT START domain in complex with compound E16
Release Data : 2019-02-27
Compound :
mol_id molecule chains synonym
1 LIPID-TRANSFER PROTEIN CERT A Ceramide transfer protein,hCERT,StAR-related lipid transfer protein 11
fragment: UNP residues 364-598
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: CERT
expression_system_strain: BL21(DE3)
expression_system_vector_type: pET28b
expression_system_plasmid: pET28b-His-3C-CERT START
Authors : Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Keywords : CERT, PH, START, COMPLEX, LIPID TRANSPORT
Exp. method : X-RAY DIFFRACTION ( 1.9000 Å )
Citation :

Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT

Nakao, N.,Ueno, M.,Sakai, S.  et al.
(2019)  Commun Chem 

DOI: 10.1038/s42004-019-0118-3

Reaction

Chain : A
UniProt : Q9Y5P4 (CERT_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
N-hexadecanoylsphing-4-enine(in) = N-hexadecanoylsphing-4- enine(out) - UniProtKB:Q6VVX2
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