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Ligands
Code Name Style Show Link
9K9 2-amino-9-[(2s,3ar,4r,6r,6ar)-2-hydroxy-6-(hydroxymethyl)-2-oxotetrahydro-2h-2lambda~5~-furo[3,4-D][1,3,2]dioxaphosphol-4-yl]-3,9-dihydro-6h-purin-6-one
SO4 Sulfate ion
Non-standard Residues
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Glycosylation
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NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show
Code : 5ZSL   PDBj   RCSB PDB   PDBe
Header : IMMUNE SYSTEM
Title : Crystal structure of monkey TLR7 in complex with GGUUGG
Release Data : 2019-01-30
Compound :
mol_id molecule chains
1 Toll-like receptor 7 B,A
fragment: UNP residues 27-839
mutation: N167Q,N389Q,N488Q,N799Q
mol_id molecule chains
2 RNA (5'-R(P*UP*UP*GP*A)-3') D,E
Source :
mol_id organism_scientific organism_common expression_system
1 Macaca mulatta  (taxid:9544) Rhesus macaque Drosophila melanogaster  (taxid:7227)
gene: TLR7
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Zhang, Z., Ohto, U., Shimizu, T.
Keywords : Innate immunity Toll-like receptors, IMMUNE SYSTEM
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.

Zhang, Z.,Ohto, U.,Shibata, T.  et al.
(2018)  Cell Rep  25 : 3371 - 3381.e5

PubMed: 30566863
DOI: 10.1016/j.celrep.2018.11.081

Chain : B, A
UniProt : B3Y653 (B3Y653_MACMU)
Reaction : -