PDB ID: 5ZR3
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Structure summary
Code : | 5ZR3 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | CHAPERONE | ||||||||||||
Title : | Crystal structure of Hsp90-alpha N-terminal domain in complex with 4-(3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-B]pyridin-1-yl)-3-methylbenzamide | ||||||||||||
Release Data : | 2019-01-02 | ||||||||||||
Compound : |
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Source : |
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Authors : | Uno, T., Chong, K.T., Suzuki, T. | ||||||||||||
Keywords : | Inhibitor, Complex, CHAPERONE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.5000 Å ) | ||||||||||||
Citation : |
Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor.
Uno, T.,Kawai, Y.,Yamashita, S.
et al.
PubMed: 30525599 |
Reaction
Chain : | A, C, E, G | ||||||||
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UniProt : | P07900 (HS90A_HUMAN) | ||||||||
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