Code : |
5ZQO
PDBj
RCSB PDB
PDBe
|
Title : |
Tankyrase-2 in complex with compound 1a |
Release Data : |
2019-04-03 |
Compound : |
mol_id |
molecule |
chains |
synonym
|
1 |
Tankyrase-2
|
A
|
TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein
|
|
ec: 2.4.2.30
|
mol_id |
molecule |
chains |
synonym
|
2 |
Tankyrase-2
|
B
|
TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein
|
|
ec: 2.4.2.30
|
|
Source : |
mol_id |
organism_scientific |
organism_common
|
expression_system
|
1 |
Homo sapiens
(taxid:9606)
|
Human
|
Cell-free synthesis
(taxid:32644)
|
|
gene: TNKS2, PARP5B, TANK2, TNKL
expression_system_vector_type: plasmid
expression_system_plasmid: pCR2.1TOPO
|
mol_id |
organism_scientific |
organism_common
|
expression_system
|
2 |
Homo sapiens
(taxid:9606)
|
Human
|
Cell-free synthesis
(taxid:32644)
|
|
gene: TNKS2, PARP5B, TANK2, TNKL
expression_system_vector_type: plasmid
expression_system_plasmid: pCR2.1TOPO
|
|
Authors : |
Niwa, H., Shirai, F., Sato, S., Yoshimoto, N., Tsumura, T., Okue, M., Shirouzu, M., Seimiya, H., Umehara, T. |
Keywords : |
Tankyrase, PARP, ADP-ribosylation, Transferase, Inhibitor, Transferase-transferase inhibitor complex |
Exp. method : |
X-RAY DIFFRACTION ( 2.06 Å ) |
Citation : |
Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
Shirai, F.,Tsumura, T.,Yashiroda, Y.
et al.
(2019)
J. Med. Chem.
62
: 3407
- 3427
PubMed: 30883102
DOI: 10.1021/acs.jmedchem.8b01888
|