Brand  (β version)

PDB ID: 5ZJC

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Code Name Style Show Link
9EX (2s)-2-methyl-3-sulfanyl-propan-1-ol PoSSuM
EDO 1,2-ethanediol PoSSuM
ZN Zinc ion PoSSuM

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Structure summary

Code : 5ZJC   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of NDM-1 in complex with D-captopril derivative CY41
Release Data : 2019-03-20
Compound :
mol_id molecule chains synonym
1 Metallo-beta-lactamase type 2 A B2 metallo-beta-lactamase,Beta-lactamase type II,Metallo-beta-lactamase NDM-1,Metallo-beta-lactamase type II,New Delhi metallo-beta-lactamase-1,NDM-1
ec: 3.5.2.6
Source :
mol_id organism_scientific expression_system
1 Klebsiella pneumoniae  (taxid:573) Escherichia coli BL21(DE3)  (taxid:469008)
gene: blaNDM-1
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pRHisMBP
Authors : Zhang, H., Hao, Q.
Keywords : NDM-1, metallo-beta-lactamase, antibiotic resistent, inhibitor, thio compounds, ANTIBIOTIC, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 0.9600 Å )
Citation :

Crystal structure of NDM-1

Zhang, H.,Hao, Q.
to be published 

Reaction

Chain : A
UniProt : C7C422 (BLAN1_KLEPN)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PubMed:19770275
-
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:22713171
ECO:0000269 | PubMed:25815530
Binds 2 Zn(2+) ions per subunit.