Het-PDB Navi2 (PDB: 5ZHK)

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Ligands
Code	Name		Style	Show	Link
9D6	N-[(4-{[cyclohexyl(ethyl)amino]methyl}phenyl)methyl]-4-oxo-3,4-dihydrothieno[2,3-D]pyrimidine-5-carboxamide				PoSSuM

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Download interaction data: 5ZHK

Code :

5ZHK PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of TrmD from Mycobacterium tuberculosis in complex with active-site inhibitor

Release Data :

2019-03-06

Compound :

mol_id	molecule	chains	synonym
1	tRNA (guanine-N(1)-)-methyltransferase	A	tRNA [GM37] methyltransferase
	ec: 2.1.1.228

Source :

mol_id	organism_scientific	expression_system
1	Mycobacterium tuberculosis H37Rv (taxid:83332)	Escherichia coli BL21(DE3) (taxid:469008)
	strain: H37Rv gene: trmD expression_system_strain: BL21(DE3)

Authors :

Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.

Keywords :

tRNA methyltransferase, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.30 Å )

Citation :

Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.

Zhong, W.,Pasunooti, K.K.,Balamkundu, S. et al.
(2019) J.Med.Chem. 62 : 7788 - 7805

PubMed: 31442049
DOI: 10.1021/acs.jmedchem.9b00582

Chain :

UniProt :

P9WFY7 (TRMD_MYCTU)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)- methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine	2.1.1.228	-
	-	-

PDB ID: 5ZHK

Hetero Atom Contents

Structure summary

Reaction