Het-PDB Navi2 (PDB: 5ZH3)

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Ligands
Code	Name		Style	Show	Link
9CF	(3s)-6,8-dihydroxy-3-{[(2r,6r)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1h-2-benzopyran-1-one				PoSSuM
LYS	Lysine				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5ZH3

Code :

5ZH3 PDBj RCSB PDB PDBe

Header :

LIGASE/LIGASE INHIBITOR

Title :

CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-6

Release Data :

2018-06-27

Compound :

mol_id	molecule	chains	synonym
1	Lysine-tRNA ligase	A,B	Lysyl-tRNA synthetase
	ec: 6.1.1.6 fragment: UNP residues 15-521

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Plasmodium falciparum NF54 (taxid:5843)	Plasmodium falciparum (isolate NF54)	Escherichia coli BL21 (taxid:511693)
	gene: PFNF54_04763 expression_system_strain: BL21 expression_system_vector_type: PETM11

Authors :

Babbar, P., Malhotra, N., Sharma, M., Harlos, K., Reddy, D.S., Manickam, Y., Sharma, A.

Keywords :

KRS, LIGASE-LIGASE INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.8600 Å )

Citation :

Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite

Das, P.,Babbar, P.,Malhotra, N. et al.
(2018) J. Med. Chem. 61 : 5664 - 5678

Chain :

A, B

UniProt :

W7JP72 (W7JP72_PLAFO)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl- tRNA(Lys)	6.1.1.6	ARBA:ARBA00000204, RuleBase:RU003748
	-	ARBA:ARBA00000204, RuleBase:RU003748

PDB ID: 5ZH3