Het-PDB Navi2 (PDB: 5ZG3)

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Ligands
Code	Name	Link
9C6	9-(4-phenoxyphenyl)-3,4-dihydro-2h-2lambda~6~-pyrido[2,1-C][1,2,4]thiadiazine-2,2-dione	PoSSuM
GLU	Glutamic acid	PoSSuM
ZN	Zinc ion	PoSSuM
ACT	Acetate ion	PoSSuM

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Download interaction data: 5ZG3

Code :

5ZG3 PDBj RCSB PDB PDBe

Header :

TRANSPORT PROTEIN

Title :

Crystal structure of the GluA2o LBD in complex with glutamate and TAK-137

Release Data :

2019-01-16

Compound :

mol_id	molecule	chains	synonym
1	Glutamate receptor 2	A,B,C,D,E,F	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
	fragment: UNP residues 413-527,UNP residues 653-796

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: GLUR2

Authors :

Sogabe, S., Igaki, S., Hirokawa, A., Zama, Y., Lane, W., Snell, G.

Keywords :

AMPA RECEPTOR LIGAND-BINDING DOMAIN, ALLOSTERIC MODULATION COMPLEX, MEMBRANE PROTEIN, TRANSPORT PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 1.65 Å )

Citation :

TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.

Kunugi, A.,Tanaka, M.,Suzuki, A. et al.
(2019) Neuropsychopharmacology 44 : 961 - 970

PDB ID: 5ZG3