Het-PDB Navi2 (PDB: 5ZA1)

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Ligands
Code	Name	Link
9A0	2-[4-({[4-(ethylsulfonyl)phenyl]acetyl}amino)phenyl]-2-methyl-N-phenylpropanamide	PoSSuM
EDO	1,2-ethanediol	PoSSuM
DMF	Dimethylformamide	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5ZA1

Code :

5ZA1 PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION

Title :

Ligand complex of RORgt LBD

Release Data :

2018-10-31

Compound :

mol_id	molecule	chains	synonym
1	Nuclear receptor ROR-gamma	A,B	Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma
	fragment: UNP residues 265-494

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: RORC, NR1F3, RORG, RZRG

Authors :

Yamamoto, S., Yamaguchi, H.

Keywords :

TRANSCRIPTION, RORgt LIGAND, RORgt inhibitor, STRUCTURE-BASED DESIGN

Exp. method :

X-RAY DIFFRACTION ( 2.5200 Å )

Citation :

Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (ROR gamma t) inhibitor, S18-000003.

Sasaki, Y.,Odan, M.,Yamamoto, S. et al.
(2018) Bioorg. Med. Chem. Lett. 28 : 3549 - 3553

PDB ID: 5ZA1