Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
92C (3z)-5-chloro-3-[(1-methyl-1h-pyrazol-4-yl)methylidene]-1,3-dihydro-2h-indol-2-one
CL Chloride ion
GOL Glycerol
PGE Triethylene glycol
Non-standard Residues
Code Name Show
CAS S-(dimethylarsenic)cysteine
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 5YVB   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure of CaMKK2 in complex with CKI-011
Release Data : 2018-12-05
Compound :
mol_id molecule chains synonym
1 Calcium/calmodulin-dependent protein kinase kinase 2 A CaMKK 2,Calcium/calmodulin-dependent protein kinase kinase beta,CaMKK beta
ec: 2.7.11.17
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human CELL-FREE SYNTHESIS  (taxid:32644)
gene: CAMKK2, CAMKKB, KIAA0787
expression_system_vector_type: Plasmid
expression_system_plasmid: PX070406-05
Authors : Niwa, H., Handa, N., Yokoyama, S.
Keywords : ATP-BINDING, KINASE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, PROTEIN-INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.02 Å )
Citation :

Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method.

Takaya, D.,Niwa, H.,Mikuni, J.  et al.
(2020)  J.Mol.Graph.Model.  99 : 107599 - 107599

PubMed: 32348940
DOI: 10.1016/j.jmgm.2020.107599

Chain : A
UniProt : Q96RR4 (KKCC2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.17 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.17 -
-