Brand  (β version)

PDB ID: 5YTG

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Ligands
Code Name Style Show Link
DGT 2'-deoxyguanosine-5'-triphosphate PoSSuM
GOL Glycerol PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
Code Name Show
94O 3-(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-2h-indeno[2',1':5,6]pyrido[2,3-D]pyrimidine-2,6(3h)-dione
DOC 2',3'-dideoxycytidine-5'-monophosphate
Glycosylation
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Modification
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Structure summary

Code : 5YTG   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/DNA
Title : Structure of large fragment of DNA Polymerase I from Thermus aquaticus Host-Guest complex with the unnatural base I-fC pair with dA
Release Data : 2018-11-21
Compound :
mol_id molecule chains synonym
1 DNA polymerase I, thermostable A Taq polymerase 1
ec: 2.7.7.7
mol_id molecule chains
2 DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3') B
mol_id molecule chains
3 DNA (5'-D(*AP*AP*AP*CP*GP*GP*CP*GP*CP*CP*GP*(94O)P*GP*GP*TP*C)-3') C
Source :
mol_id organism_scientific expression_system
1 Thermus aquaticus  (taxid:271) Escherichia coli  (taxid:562)
gene: polA, pol1
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
mol_id organism_scientific
3 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Zeng, H., Mondal, M., Song, R.Y., Zhang, J., Xia, B., Gao, Y.Q., Yi, C.Q.
Keywords : DNA, REPLICATION, TRANSFERASE-DNA complex
Exp. method : X-RAY DIFFRACTION ( 2.07 Å )
Citation :

Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry.

Zeng, H.,Mondal, M.,Song, R.  et al.
(2019)  Angew. Chem. Int. Ed. Engl.  58 : 130 - 133

PubMed: 30407705
DOI: 10.1002/anie.201807845

Reaction

Chain : A
UniProt : P19821 (DPO1_THEAQ)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 -
-