Het-PDB Navi2 (PDB: 5YLT)

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Ligands
Code	Name	Link
C7N	2-(1-methylpiperidin-4-ylidene)tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-6-ol	PoSSuM
GOL	Glycerol	PoSSuM
SFG	Sinefungin	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5YLT

Code :

5YLT PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal structure of SET7/9 in complex with a cyproheptadine derivative

Release Data :

2018-06-20

Compound :

mol_id	molecule	chains	synonym
1	Histone-lysine N-methyltransferase SETD7	A	Histone H3-K4 methyltransferase SETD7,H3-K4-HMTase SETD7,Lysine N-methyltransferase 7,SET domain-containing protein 7,SET7/9
	ec: 2.1.1.43

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	CELL-FREE SYNTHESIS (taxid:32644)
	gene: SETD7, KIAA1717, KMT7, SET7, SET9 expression_system_vector_type: PLASMID expression_system_plasmid: PX100709-08

Authors :

Hirano, T., Fujiwara, T., Niwa, H., Hirano, M., Ohira, K., Okazaki, Y., Sato, S., Umehara, T., Maemoto, Y., Ito, A., Yoshida, M., Kagechika, H.

Keywords :

Set domain, methyltransferase, inhibitor, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.690 Å )

Citation :

Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine.

Hirano, T.,Fujiwara, T.,Niwa, H. et al.
(2018) ChemMedChem 13 : 1530 - 1540

Chain :

UniProt :

Q8WTS6 (SETD7_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine	2.1.1.364	PROSITE-ProRule:PRU00910, PubMed:12540855
	-	PROSITE-ProRule:PRU00910, PubMed:12540855
L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine	-	PubMed:15099517, PubMed:15525938, PubMed:16415881
	left-to-right	PubMed:15099517, PubMed:15525938, PubMed:16415881

PDB ID: 5YLT