Brand  (β version)

PDB ID: 5XSP

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Ligands
Code Name Style Show Link
A Adenosine-5'-monophosphate PoSSuM
MN Manganese (II) ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5XSP   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : The catalytic domain of GdpP with 5'-pApA
Release Data : 2018-01-31
Compound :
mol_id molecule chains
1 Phosphodiesterase acting on cyclic dinucleotides A,B
fragment: UNP residues 322-661
Source :
mol_id organism_scientific expression_system
1 Staphylococcus aureus  (taxid:1280) Escherichia coli BL21(DE3)  (taxid:469008)
gene: cdnD, BN1321_430104
expression_system_strain: BL21(DE3)
Authors : Wang, F., Gu, L.
Keywords : phosphodiesterase, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.146 Å )
Citation :

Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase

Wang, F.,He, Q.,Su, K.  et al.
(2018)  Biochem. J.  475 : 191 - 205

PubMed: 29203646
DOI: 10.1042/BCJ20170739

Reaction

Chain : A, B
UniProt : A0A0U1MUE2 (A0A0U1MUE2_STAAU)
Reaction: EC: Evidence:
Physiological Direction:
3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'->5')- adenosine + H(+) - PIRNR:PIRNR026583
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