Brand  (β version)

PDB ID: 5XE1

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Ligands
Code Name Style Show Link
HEM Protoporphyrin ix containing Fe PoSSuM
IUU 4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboxamidine PoSSuM
Non-standard Residues
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Structure summary

Code : 5XE1   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with INCB14943
Release Data : 2017-05-03
Compound :
mol_id molecule chains synonym
1 Indoleamine 2,3-dioxygenase 1 A,B IDO-1,Indoleamine-pyrrole 2,3-dioxygenase
ec: 1.13.11.52
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: IDO1, IDO, INDO
expression_system_strain: BL21(DE3)
Authors : Xu, J., Wu, U., Liu, J.
Keywords : IDO1, INCB14943, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 3.20 Å )
Citation :

Structural insights into the binding mechanism of IDO1 with hydroxylamidine based inhibitor INCB14943

Wu, Y.,Xu, T.,Liu, J.  et al.
(2017)  Biochem. Biophys. Res. Commun.  487 : 339 - 343

PubMed: 28412361
DOI: 10.1016/j.bbrc.2017.04.061

Reaction

Chain : A, B
UniProt : P14902 (I23O1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
D-tryptophan + O2 = N-formyl-D-kynurenine 1.13.11.52 PubMed:17671174
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L-tryptophan + O2 = N-formyl-L-kynurenine 1.13.11.52 PubMed:17671174
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