PDB ID: 5X02
Hetero Atom Contents
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F6M | N-[(2s)-1-[5-[2-[(4-cyanophenyl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxidanylidene-propan-2-yl]-4-(dimethylamino)-N-methyl-but-2-enamide | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM |
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Download interaction data: 5X02
Structure summary
Code : | 5X02 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE INIHIBITOR | ||||||||||||
Title : | Crystal structure of the FLT3 kinase domain bound to the inhibitor FF-10101 | ||||||||||||
Release Data : | 2018-01-24 | ||||||||||||
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Authors : | Fujikawa, N., Hirano, D., Takasaki, M., Terada, D., Hagiwara, S., Park, S.-Y., Sugiyama, K. | ||||||||||||
Keywords : | tyrosine kinase, transferase, irreversible inhibitor complex, kinase catalytic domain, TRANSFERASE-TRANSFERASE INIHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.4010 Å ) | ||||||||||||
Citation : |
A novel irreversible FLT3 inhibitor, FF-10101, shows excellent efficacy against AML cells withFLT3mutations.
Yamaura, T.,Nakatani, T.,Uda, K.
et al.
PubMed: 29187377 |
Reaction
Chain : | A | ||||||||
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UniProt : | P36888 (FLT3_HUMAN) | ||||||||
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