Het-PDB Navi2 (PDB: 5WYX)

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Ligands
Code	Name		Style	Show	Link
CU8	7-(3-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize
BMA	Beta-D-mannopyranose
MAN	Alpha-D-mannopyranose
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
Code	Name	Show

Download interaction data: 5WYX

Code :

5WYX PDBj RCSB PDB PDBe

Header :

IMMUNE SYSTEM

Title :

Crystal structure of human TLR8 in complex with CU-CPT8m

Release Data :

2017-12-13

Compound :

mol_id	molecule	chains
1	Toll-like receptor 8	A,B
	fragment: Extracellular domain, UNP residues 27-827

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Drosophila (taxid:7215)
	gene: TLR8, UNQ249/PRO286

Authors :

Tanji, H., Ohto, U., Shimizu, T.

Keywords :

IMMUNE SYSTEM

Exp. method :

X-RAY DIFFRACTION ( 2.40 Å )

Citation :

Small-molecule inhibition of TLR8 through stabilization of its resting state

Zhang, S.,Hu, Z.,Tanji, H. et al.
(2018) Nat. Chem. Biol. 14 : 58 - 64

PDB ID: 5WYX