Brand  (β version)

PDB ID: 5W7E

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
FAW (2s)-3-hydroxypropane-1,2-diyl ditetradecanoate PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 5W7E   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Murine acyloxyacyl hydrolase (AOAH), S262A mutant, with dimyristoyl phosphatidylcholine
Release Data : 2018-01-03
Compound :
mol_id molecule chains
1 Acyloxyacyl hydrolase A,B
ec: 3.1.1.77
fragment: residues 23-574
mutation: S262A
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Spodoptera frugiperda  (taxid:7108)
gene: Aoah
expression_system_common: Fall armyworm
Authors : Gorelik, A., Illes, K., Nagar, B.
Keywords : lipopolysaccharide, LPS, GDSL esterase, saposin, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.830 Å )
Citation :

Crystal structure of the mammalian lipopolysaccharide detoxifier.

Gorelik, A.,Illes, K.,Nagar, B.
(2018)  Proc. Natl. Acad. Sci. U.S.A.  115 : E896 - E905

PubMed: 29343645
DOI: 10.1073/pnas.1719834115

Reaction

Chain : A, B
UniProt : O35298 (AOAH_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = 3- hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+) 3.1.1.77 PubMed:12810692, PubMed:15155618, PubMed:17322564, PubMed:18779055, PubMed:19860560
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