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Ligands
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9WD 1-{4-[(R)-(4-chloro-2-methoxy-3-{[4-(1h-pyrazol-1-yl)phenyl]methyl}quinolin-6-yl)(hydroxy)(1-methyl-1h-imidazol-5-yl)methyl]piperidin-1-yl}ethan-1-one
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Code : 5W4R   PDBj   RCSB PDB   PDBe
Header : NUCLEAR PROTEIN
Title : Structure of RORgt bound to a tertiary alcohol
Release Data : 2017-12-27
Compound :
mol_id molecule chains synonym
1 Nuclear receptor ROR-gamma A,B Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma
fragment: UNP residues 265-481
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: RORC, NR1F3, RORG, RZRG
Authors : Spurlino, J.
Keywords : RORgt Nuclear Hormone Receptor, NUCLEAR PROTEIN
Exp. method : X-RAY DIFFRACTION ( 3.0020 Å )
Citation :

6-Substituted quinolines as ROR gamma t inverse agonists.

Barbay, J.K.,Cummings, M.D.,Abad, M.  et al.
(2017)  Bioorg. Med. Chem. Lett.  27 : 5277 - 5283

PubMed: 29079472
DOI: 10.1016/j.bmcl.2017.10.027

Chain : A, B
UniProt : P51449 (RORG_HUMAN)
Reaction : -