Het-PDB Navi2 (PDB: 5VT1)

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Ligands
Code	Name		Style	Show	Link
9JS	4-({5-[(3-hydroxy-4-methylphenyl)amino]-4-oxo-4h-1,2,6-thiadiazin-3-yl}amino)benzamide				PoSSuM
MG	Magnesium ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5VT1

Code :

5VT1 PDBj RCSB PDB PDBe

Header :

Transferase/Transferase Inhibitor

Title :

Crystal Structure of the Human CAMKK2B bound to a thiadiazinone benzamide inhibitor

Release Data :

2017-05-24

Compound :

mol_id	molecule	chains	synonym
1	Calcium/calmodulin-dependent protein kinase kinase 2	A	CaMKK 2,Calcium/calmodulin-dependent protein kinase kinase beta,CaMKK beta
	ec: 2.7.11.17 fragment: UNP residues 161-449

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: CAMKK2, CAMKKB, KIAA0787 expression_system_strain: BL21(DE3) expression_system_variant: R3 expression_system_vector_type: plasmid

Authors :

Counago, R.M., Asquith, C.R.M., Arruda, P., Edwards, A.M., Gileadi, O., Kalogirou, A.S., Koutentis, P.A., Structural Genomics Consortium (SGC)

Keywords :

transferase, protein kinase domain, Structural Genomics, Structural Genomics Consortium, SGC, Transferase-Transferase Inhibitor Complex

Exp. method :

X-RAY DIFFRACTION ( 1.90 Å )

Citation :

1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors.

Asquith, C.R.M.,Godoi, P.H.,Counago, R.M. et al.
(2018) Molecules 23

Chain :

UniProt :

Q96RR4 (KKCC2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.17	-
	-	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.17	-
	-	-

PDB ID: 5VT1