Het-PDB Navi2 (PDB: 5VPY)

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Ligands
Code	Name		Style	Show	Link
MG	Magnesium ion				PoSSuM
9GM	2-amino-9-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-alpha-L-xylofuranosyl}-1,9-dihydro-6h-purin-6-one				PoSSuM

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Download interaction data: 5VPY

Code :

5VPY PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of human KRAS G12A mutant in complex with GppNHp

Release Data :

2017-12-06

Compound :

mol_id	molecule	chains	synonym
1	GTPase KRas	A,B	K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
	fragment: residues 1-169 mutation: G12A, C118S

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: KRAS, KRAS2, RASK2

Authors :

Xu, S., Long, B., Boris, G., Ni, S., Kennedy, M.A.

Keywords :

Oncogenic mutant, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.0000 Å )

Citation :

Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras.

Xu, S.,Long, B.N.,Boris, G.H. et al.
(2017) Acta Crystallogr D Struct Biol 73 : 970 - 984

Chain :

A, B

UniProt :

P01116 (RASK_HUMAN)

PDB ID: 5VPY