Het-PDB Navi2 (PDB: 5VOM)

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Ligands
Code	Name		Style	Show	Link
9GY	3-[(2s)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-6-yl]-N-methylbenzamide				PoSSuM

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Download interaction data: 5VOM

Code :

5VOM PDBj RCSB PDB PDBe

Header :

Transcription/Inhibitor

Title :

Benzopiperazine BET bromodomain inhibitor in complex with BD1 of Brd4

Release Data :

2017-08-02

Compound :

mol_id	molecule	chains	synonym
1	Bromodomain-containing protein 4	A,B	Protein HUNK1

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:511693)
	gene: BRD4, HUNK1 expression_system_strain: BL21-CodonPlus

Authors :

Toms, A.V., Herbertz, T.

Keywords :

bromodomain Brd4 BET Benzopiperazine, Transcription-Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.67 Å )

Citation :

Design and Optimization of Benzopiperazines as Potent Inhibitors of BET Bromodomains.

Millan, D.S.,Kayser-Bricker, K.J.,Martin, M.W. et al.
(2017) ACS Med Chem Lett 8 : 847 - 852

PDB ID: 5VOM