Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
9GY 3-[(2s)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-6-yl]-N-methylbenzamide
Code : 5VOM
Header : Transcription/Inhibitor
Title : Benzopiperazine BET bromodomain inhibitor in complex with BD1 of Brd4
Release Data : 2017-08-02
Compound :
mol_id molecule chains synonym
1 Bromodomain-containing protein 4 A,B Protein HUNK1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:511693)
gene: BRD4, HUNK1
expression_system_strain: BL21-CodonPlus
Authors : Toms, A.V., Herbertz, T.
Keywords : bromodomain Brd4 BET Benzopiperazine, Transcription-Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.67 Å )
Citation :

Design and Optimization of Benzopiperazines as Potent Inhibitors of BET Bromodomains.

Millan, D.S.,Kayser-Bricker, K.J.,Martin, M.W.  et al.
(2017)  ACS Med Chem Lett  8 : 847 - 852

PubMed: 28835800
DOI: 10.1021/acsmedchemlett.7b00191

Chain : A, B
UniProt : O60885 (BRD4_HUMAN)
Reaction : -