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Ligands
Code Name Style Show Link
9FG 5-(2-fluoro-4-hydroxyphenyl)-1-methyl-1h-pyrrole-2-carbonitrile
Non-standard Residues
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Glycosylation
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Code : 5VO4   PDBj   RCSB PDB   PDBe
Header : HORMONE RECEPTOR
Title : Crystal Structure Of The Androgen Receptor Ligand Binding Domain In Complex With 5-(2-fluoro-4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carbonitrile
Release Data : 2018-03-14
Compound :
mol_id molecule chains synonym
1 Androgen receptor A Dihydrotestosterone receptor,Nuclear receptor subfamily 3 group C member 4
fragment: UNP residues 671-920
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli-Pichia pastoris shuttle vector pPpARG4  (taxid:1182032)
gene: AR, DHTR, NR3C4
Authors : Parris, K., Unwalla, R.
Keywords : receptor, small molecule inhibitor, HORMONE RECEPTOR
Exp. method : X-RAY DIFFRACTION ( 2.35 Å )
Citation :

Structure-Based Approach To Identify 5-[4-Hydroxyphenyl]pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators.

Unwalla, R.,Mousseau, J.J.,Fadeyi, O.O.  et al.
(2017)  J. Med. Chem.  60 : 6451 - 6457

PubMed: 28696695
DOI: 10.1021/acs.jmedchem.7b00373

Chain : A
UniProt : P10275 (ANDR_HUMAN)
Reaction : -