Brand  (β version)

PDB ID: 5VIE

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Ligands
Code Name Style Show Link
UDP Uridine-5'-diphosphate PoSSuM
9C1 2-{[(2e)-4-chlorobut-2-enoyl]amino}-2-deoxy-beta-D-glucopyranose PoSSuM
9CD 2-{[(2e)-but-2-enoyl]amino}-2-deoxy-beta-D-glucopyranose PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5VIE   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase
Release Data : 2017-10-18
Compound :
mol_id molecule chains synonym
1 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit A,C O-GlcNAc transferase subunit p110,O-linked N-acetylglucosamine transferase 110 kDa subunit,OGT
ec: 2.4.1.255
fragment: UNP residues 323-1041
mol_id molecule chains
2 CKII B,D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: OGT
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
synthetic: yes
Authors : Jiang, J., Li, B., Hu, C.-W., Worth, M., Fan, D., Li, H.
Keywords : O-GlcNAc Transferase, Electrophilic Probes, complex, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase.

Hu, C.W.,Worth, M.,Fan, D.  et al.
(2017)  Nat. Chem. Biol.  13 : 1267 - 1273

PubMed: 29058723
DOI: 10.1038/nchembio.2494

Reaction

Chain : A, C
UniProt : O15294 (OGT1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N- acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP 2.4.1.255 PubMed:15361863, PubMed:21240259, PubMed:21285374, PubMed:23103939, PubMed:24563466, PubMed:27713473, PubMed:30699359, PubMed:34074792, PubMed:26369908, PubMed:26678539
left-to-right PubMed:24563466, PubMed:27713473, PubMed:30699359, PubMed:34074792
L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O- (N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP 2.4.1.255 PubMed:15361863, PubMed:21240259, PubMed:21285374, PubMed:24563466, PubMed:37541260, PubMed:26678539
left-to-right PubMed:24563466, PubMed:27713473, PubMed:37541260
[Isoform 4]
L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N- acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP 		2.4.1.255 PubMed:31527085
left-to-right
[Isoform 4]
L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O- (N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP 		2.4.1.255 PubMed:31527085
left-to-right