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Ligands
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9BA N-{(3r,6s,9s,12r)-6-ethyl-12-methyl-9-[3-(N'-methylcarbamimidamido)propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl}-2-methylpropanamide
EDO 1,2-ethanediol
SO4 Sulfate ion
Non-standard Residues
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Code : 5VFC   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION/INHIBITOR
Title : WDR5 bound to inhibitor MM-589
Release Data : 2017-06-28
Compound :
mol_id molecule chains synonym
1 WD repeat-containing protein 5 A BMP2-induced 3-kb gene protein
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: WDR5, BIG3
Authors : Stuckey, J.A.
Keywords : inhibitor, complex, WD repeat, TRANSCRIPTION, TRANSCRIPTION-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.64 Å )
Citation :

Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.

Karatas, H.,Li, Y.,Liu, L.  et al.
(2017)  J. Med. Chem.  60 : 4818 - 4839

PubMed: 28603984
DOI: 10.1021/acs.jmedchem.6b01796

Chain : A
UniProt : P61964 (WDR5_HUMAN)
Reaction : -