Brand  (β version)

PDB ID: 5VEU

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Ligands
Code Name Style Show Link
HEM Protoporphyrin ix containing Fe PoSSuM
RIT Ritonavir PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5VEU   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor
Title : Human Cytochrome P450 3A5 (CYP3A5)
Release Data : 2017-11-15
Compound :
mol_id molecule chains synonym
1 Cytochrome P450 3A5 A,B,C,D,E,F,G,H,I,J,K,L CYPIIIA5,Cytochrome P450 HLp2,Cytochrome P450-PCN3
ec: 1.14.14.1
fragment: UNP residues 24-497
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CYP3A5
expression_system_strain: DH-5a
expression_system_vector_type: plasmid
expression_system_plasmid: pCWori
Authors : Hsu, M.-H., Johnson, E.F.
Keywords : Inhibitor, Complex, Cytochrome P450, ritonavir, CYP3A5, OXIDOREDUCTASE-OXIDOREDUCTASE inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.910 Å )
Citation :

The X-Ray Crystal Structure of the Human Mono-Oxygenase Cytochrome P450 3A5-Ritonavir Complex Reveals Active Site Differences between P450s 3A4 and 3A5.

Hsu, M.H.,Savas, U.,Johnson, E.F.
(2018)  Mol. Pharmacol.  93 : 14 - 24

PubMed: 29093019
DOI: 10.1124/mol.117.109744

Reaction

Chain : A, B, C, D, E, F, G, H, I, J, K, L
UniProt : P20815 (CP3A5_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] 1.14.14.1 PubMed:11093772, PubMed:12865317, PubMed:2732228
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17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH-- hemoprotein reductase] - PubMed:12865317
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17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH-- hemoprotein reductase] - PubMed:12865317
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estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2- hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] - PubMed:12865317
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estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4- hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] - PubMed:12865317
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O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] - PubMed:2732228
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androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] - PubMed:2732228
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O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] - PubMed:2732228
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all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH-- hemoprotein reductase] - PubMed:10681376
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all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] - PubMed:11093772
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