Brand  (β version)

PDB ID: 5VD7

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Ligands
Code Name Style Show Link
99V 6-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-D]pyrimidin-3-one PoSSuM
CL Chloride ion PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Structure summary

Code : 5VD7   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WITH RAC-IV-098, a MK1775 analogue
Release Data : 2018-04-04
Compound :
mol_id molecule chains synonym
1 Wee1-like protein kinase A WEE1hu,Wee1A kinase
ec: 2.7.10.2
fragment: UNP RESIDUES 291-575
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human ESCHERICHIA COLI  (taxid:469008)
gene: WEE1
expression_system_strain: BL21(DE3)-RIPL
expression_system_vector_type: PLASMID
expression_system_plasmid: pET28a
Authors : Zhu, J.-Y., Schonbrunn, E.
Keywords : KINASE DOMAIN, CELL CYCLE, WEE1, TRANSFERASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.0800 Å )
Citation :

Structural basis of Wee family kinase inhibition by small molecules

Zhu, J.-Y.,Schonbrunn, E.
to be published 

Reaction

Chain : A
UniProt : P30291 (WEE1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10027
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