Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
UNX Unknown atom or ion
Modified Residues
Code Name Link
DN Unknown 2'-deoxynucleotide
MSE Selenomethionine
Code : 5VC8
Header : DNA BINDING PROTEIN
Title : Crystal structure of the WHSC1 PWWP1 domain
Release Data : 2017-06-28
Compound :
mol_id molecule chains synonym
1 Histone-lysine N-methyltransferase NSD2 A,B Multiple myeloma SET domain-containing protein,MMSET,Nuclear SET domain-containing protein 2,Protein trithorax-5,Wolf-Hirschhorn syndrome candidate 1 protein
ec: 2.1.1.43
mol_id molecule chains
2 dodeca-2-deoxy-nucleotide, poorly resolved by electron density W,X,Y
mol_id molecule chains
3 DNA (5'-D(P*CP*TP*(DN))-3') Z
other_details: Interpretation of weak electron density in terms of an unidentified fragment of the dodecadeoxynucleotide.
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: NSD2, KIAA1090, MMSET, TRX5, WHSC1
expression_system_strain: BL21(DE3)-V2R-pRARE2
expression_system_plasmid: pET28-MHL
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
mol_id organism_scientific
3 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Qin, S., Tempel, W., Dong, A., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Keywords : PWWP domain, Structural Genomics Consortium, DNA BINDING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.8000 Å )
Citation :

Crystal structure of the WHSC1 PWWP1 domain

Qin, S.,Tempel, W.,Dong, A.  et al.
To Be Published 

Chain : A, B
UniProt : O96028 (NSD2_HUMAN)
Reaction : S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].