PDB ID: 5VAM
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Structure summary
Code : | 5VAM PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE inhibitor | ||||||||||||
Title : | BRAF in Complex with RAF709 | ||||||||||||
Release Data : | 2017-06-28 | ||||||||||||
Compound : |
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Source : |
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Authors : | Mamo, M., Appleton, B.A. | ||||||||||||
Keywords : | BRAF Serine/threonine-protein kinase B-raf, TRANSFERASE-TRANSFERASE inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.1000 Å ) | ||||||||||||
Citation : |
Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.
Nishiguchi, G.A.,Rico, A.,Tanner, H.
et al.
PubMed: 28557458 |
Reaction
Chain : | A, B | ||||||||||||
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UniProt : | P15056 (BRAF_HUMAN) | ||||||||||||
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