Het-PDB Navi2 (PDB: 5VAD)

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Ligands
Code	Name	Link
91Y	3-[(cyclohexanecarbonyl)amino]-N-(2,3-dihydro-1h-inden-2-yl)pyrazine-2-carboxamide	PoSSuM
PRO	Proline	PoSSuM
ZN	Zinc ion	PoSSuM

Non-standard Residues
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Download interaction data: 5VAD

Code :

5VAD PDBj RCSB PDB PDBe

Header :

LIGASE/LIGASE inhibitor

Title :

Crystal structure of human Prolyl-tRNA synthetase (PRS) in complex with inhibitor

Release Data :

2017-05-31

Compound :

mol_id	molecule	chains	synonym
1	Bifunctional glutamate/proline--tRNA ligase	A,B	Bifunctional aminoacyl-tRNA synthetase,Cell proliferation-inducing gene 32 protein,Glutamatyl-prolyl-tRNA synthetase
	ec: 6.1.1.17,6.1.1.15 fragment: UNP residues 998-1512

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: EPRS, GLNS, PARS, QARS, QPRS, PIG32

Authors :

Okada, K., Skene, R.J.

Keywords :

aminoacyl-tRNA synthetase, ATP dependent, inhibitor, LIGASE-LIGASE inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.3600 Å )

Citation :

Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l-proline.

Adachi, R.,Okada, K.,Skene, R. et al.
(2017) Biochem. Biophys. Res. Commun. 488 : 393 - 399

Chain :

A, B

UniProt :

P07814 (SYEP_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L- glutamyl-tRNA(Glu)	6.1.1.17	PubMed:3290852
	left-to-right	PubMed:3290852
ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl- tRNA(Pro)	6.1.1.15	PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:37212275
	left-to-right	PubMed:24100331

PDB ID: 5VAD