PDB ID: 5V9L
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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GDP | Guanosine-5'-diphosphate | PoSSuM | |||
MG | Magnesium ion | PoSSuM | |||
91D | N~3~-[6-chloro-7-(2-fluorophenyl)-4-(4-propanoylpiperazin-1-yl)quinazolin-2-yl]-N,N-dimethyl-beta-alaninamide | PoSSuM |
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Download interaction data: 5V9L
Structure summary
Code : | 5V9L PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE/HYDROLASE inhibitor | ||||||||||||
Title : | KRAS G12C in bound to quinazoline based switch II pocket (SWIIP) binder | ||||||||||||
Release Data : | 2017-08-23 | ||||||||||||
Compound : |
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Authors : | Westover, K., Lu, J. | ||||||||||||
Keywords : | KRAS mutant inhibitor, HYDROLASE-HYDROLASE inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.9810 Å ) | ||||||||||||
Citation : |
Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.
Zeng, M.,Lu, J.,Li, L.
et al.
PubMed: 28781124 |
Reaction
Chain : | A, B, C | ||||||||
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UniProt : | P01116 (RASK_HUMAN) | ||||||||
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