Brand  (β version)

PDB ID: 5V8Q

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Ligands
Code Name Style Show Link
97A 4-[(2s,3s)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
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Structure summary

Code : 5V8Q   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs): Part III
Release Data : 2017-05-24
Compound :
mol_id molecule chains synonym
1 Androgen receptor A Dihydrotestosterone receptor,Nuclear receptor subfamily 3 group C member 4
fragment: UNP residues 140-388
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: AR, DHTR, NR3C4
Authors : Wilson, K.P.
Keywords : Androgen Receptor, selective androgen receptor modulators, SARMS, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.4400 Å )
Citation :

Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate.

Aikawa, K.,Asano, M.,Ono, K.  et al.
(2017)  Bioorg. Med. Chem.  25 : 3330 - 3349

PubMed: 28454849
DOI: 10.1016/j.bmc.2017.04.018

Reaction

Chain : A
UniProt : P10275 (ANDR_HUMAN)
Reaction : -